PSV Eindhoven surrendered their 100 per cent record in disappointing fashion after being held to a 0-0 draw at home to Groningen.
Man Utd will face Fenerbahce, Feyenoord and Zorya Luhansk in the Europa League, while Southampton are in a group with Inter Milan.
Feyenoord continued their perfect start to the season and returned to the top of the Eredivisie with a 1-0 win at Heracles Almelo.
Eredivisie champions PSV made it two wins from two as Hector Moreno's goal secured a 1-0 victory over AZ Alkmaar, on Sunday.
Eljero Elia's hat-trick helped Feyenoord win 5-0 at FC Groningen on the opening weekend of the Eredivisie.
West Ham will play Romanian champions FC Astra Giurgiu in the Europa League play-off round.
AZ Alkmaar sporting director Mark Huiberts has dismissed reports that Tottenham are close to signing their striker Vincent Janssen as "nonsense".
Dutch striker Vincent Janssen says he is frustrated with AZ Alkmaar for turning down a £15m bid from Tottenham for his transfer.
With Sky sources indicating Tottenham have held talks with Vincent Janssen, we shed some light on last season's Eredivisie top scorer.
Tottenham have held talks with Eredivisie top scorer Vincent Janssen after AZ Alkmaar gave him permission to speak to Spurs.
Ajax moved a step closer to reclaiming the Eredivisie title on Sunday with a thumping 4-0 win over FC Twente.
AZ Alkmaar took a grip of fourth place in the Eredivisie with a 2-1 win over ADO Den Haag.
PSV Eindhoven returned to the top of the Eredivisie table after a 3-0 success at Roda JC sealed a third straight win.
Feyenoord tightened their grip on third place and a Europa League qualification spot with a 1-0 win at FC Twente.
Marko van Ginkel scored twice as PSV returned to the top of the Eredivisie table with a 4-2 win at AZ Alkmaar on Saturday.
Who are the five brightest young Dutch players? We take a look ahead of their friendly with England...
Ajax won 2-0 at PSV Eindhoven to climb above their rivals to the top of the Eredivsie table on Sunday.
Eredivisie leaders PSV Eindhoven were held to a frustrating 1-1 draw by Heerenveen at Philips Stadion on Saturday.
Ajax closed the gap to Eredivisie leaders PSV Eindhoven back to a single point after thumping Willem II 4-0 on Sunday.
Eredivisie leaders PSV Eindhoven coasted to an eighth straight win to open up a four-point advantage over Ajax.